Heart fibrosis

Cardiac tissue microenvironment is a carefully regulated system, which upon disfunction can lead to chronic diseases, such as cardiomyophathy, sclerosis, ischemic diseases etc. Despite, the cardiomyocytes are primary functional cells, they are usually victims of such disfunctions. Cardiac fibroblasts, endothelial cells, and adipose tissue impact each other is numerous way, and their combination can serve as a perfect model to study cardiac homeostasis, and pathophysiological states