Preci Preci

Hematological malignancies

There is no single model, which can allow modelling all oncohematological conditions. Blood, bone marrow, and lymph nodes are active participants of the process, and need to be assessed separately in the context of oncological disease development and progression. It is important to capture personalised donor features, such as individual expression profiles. Therefore we develop multi-donor model panels to assess the activity of drugs among the population, as well to capture the resistance

Myeloid cell colonies

Reactive lymph node organoids

Bone marrow ECM-embedded organoids

Liquid tumors modelling set components

Disease range

  • Healthy bone marrow/tonsil/CD34+ cells – control
  • Acute Myeloid Leukaemia
  • Chronic Lymphocytic Leukaemia
  • Multiple Myeloma
  • Hodgkin and non-Hodgkin Lymphoma

Assays validated

  • RNAseq and target expression analysis
  • Cell killing assays
  • Apoptosis
  • Cell ratio (imaging-based)
  • Proliferation
  • T-cell activation

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