GI

Gastrointestinal tissue is exposed to constant metabolic, microbial, and inflammatory stress, which strongly affects epithelial integrity, barrier permeability, and immune homeostasis. Disruption of cross-talk between epithelial, stromal, endothelial, and immune components may lead to chronic inflammation, impaired nutrient absorption, fibrosis, and tissue injury. Therefore, incorporation of multiple cellular compartments is highly essential for predictive modelling of gastrointestinal toxicity and inflammatory responses. Preci offers gastrointestinal tissue models composed of primary epithelial cells, stromal fibroblasts, endothelial cells, and PBMCs within physiologically relevant ECM-supported microenvironments, enabling investigation of barrier disruption, inflammatory activation, cytokine secretion, immune cell infiltration, and compound-induced gastrointestinal injury in vitro.