Skin tissue is constantly exposed to chemical, mechanical, microbial, and inflammatory stress, which may disrupt barrier integrity and induce immune-mediated tissue injury. Cross-talk between keratinocytes, dermal fibroblasts, endothelial cells, and immune populations strongly regulates epidermal homeostasis, extracellular matrix remodeling, cytokine secretion, and wound repair. Therefore, incorporation of both epithelial and stromal compartments is highly essential for predictive modelling of skin toxicity, inflammation, and barrier disruption. Preci offers skin tissue models composed of primary skin-derived cells within physiologically relevant ECM-supported microenvironments, enabling investigation of compound-induced irritation, inflammatory activation, fibrotic remodeling, barrier damage, and tissue repair responses in vitro.
Skin stromal ECM-embedded layer with infiltrated isogenic immune cells
Skin modelling set components
Assays validated
- RNAseq and target expression analysis
- Inflammation cytokines sectretion
- T-cell activation
- Cell killing
- Hepatocytes death
- pAkt induction
- Albumin secretion
- Glycogen accumulation and depletion