Insights & Innovations
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The safety of newly developed lead compounds is often prioritized over efficacy. Additionally, the efficacy of a drug in a living organism may be compromised due to either too fast or too slow metabolism. Consequently, comprehensive Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADME-Tox) research becomes crucial for the development of new chemical entities. Drug metabolism […]
For three decades already researchers globally use Matrigel and similar products as a solid support for tissues in for in vitro modeling and tissue engineering. Current problems in supply prove additionally that those products are heavily used in modern days. How reliable Matrigel is? It is derived from Engelbreth-Holm-Swarm mouse sarcoma via urea-based isolation procedure. […]
Simple reliable assays render drug that are clinically useful. We all recall the succesful attempt of James Cook to discover the drug against scurvy.
In modern drug discovery, a critical factor in early-stage compound evaluation is how efficiently a candidate drug is metabolized in the liver as well as in other organs.
Our ADME and DMPK products portfolio keeps growing, and we are excited to share the latest updates in our freshly redesigned brochure.
Primary Human Hepatocytes (Pooled and Plateable) thawing may be tricky in the way for your best experimental results. The improper thawing may result in poor pool viability or insufficient cell...