Adipose

Adipose tissue acts as a highly active metabolic and endocrine organ, regulating systemic energy balance, inflammatory signaling, and glucose homeostasis. Cross-talk between adipocytes, stromal fibroblasts, endothelial cells, and immune populations strongly affects cytokine secretion, extracellular matrix remodeling, lipid metabolism, and progression of chronic inflammation. Disturbance of adipose tissue homeostasis may lead to insulin resistance, fibrosis, vascular dysfunction, and metabolic disease progression. Therefore, incorporation of multiple native cellular compartments is highly essential for predictive modelling of metabolic stress and inflammatory responses. Preci offers adipose tissue models composed of primary adipocytes together with stromal, endothelial, and immune components within physiologically relevant ECM-supported microenvironments, enabling investigation of inflammatory activation, fibrotic remodeling, glucose stress, lipid metabolism, and compound-induced metabolic toxicity in vitro.