IPF/ILD Asthma

Lung fibrosis and inflammation is a chronic condition that potentially can be fatal to the patient. Despite many attempts only few therapeutic options exist for such conditions. Lung fibrosis is associated with the fibroblasts transformation into myofibroblasts and ECM accumulation, decreasing the organ functionality. Asthma is the disease with the complex and obscure pathogenesis, which surely involves interaction between Th2 cells, airway epithelium, fibroblasts, and smooth muscle cells. Disentangling this mechanism and figuring out the role of each component will definitely lead to discovery of new therapeutic modalities. Our complex organoid models can serve as an instrument for such discoveries using human biology