Pancreas

Pancreatic tissue undergoes highly complex inflammatory and fibrotic responses upon exposure to toxic compounds, metabolic stress, and inflammatory stimuli. Cross-talk between ductal epithelial cells, stromal fibroblasts, and infiltrating immune cells strongly regulates tissue homeostasis, cytokine secretion, and progression of tissue injury. Therefore, incorporation of both stromal and immune components is highly essential for predictive pancreatic toxicity assessment. Preci offers pancreatic tissue models composed of primary ductal cells, pancreatic fibroblasts, and PBMCs within physiologically relevant ECM-supported microenvironments, enabling investigation of inflammatory activation, fibrotic remodeling, immune-mediated toxicity, and compound-induced pancreatic injury in vitro.