Insights & Innovations
Stay up to date with the latest industry trends, expert opinions, and company news shaping the future of our field.
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Primary Human Hepatocytes (Pooled and Plateable) thawing may be tricky in the way for your best experimental results. The improper thawing may result in poor pool viability or insufficient cell...
In modern drug discovery, a critical factor in early-stage compound evaluation is how efficiently a candidate drug is metabolized in the liver as well as in other organs.
In May 2024, the International Council for Harmonisation (ICH) published the final version of the M12 guideline, marking a pivotal step towards standardizing drug-drug interaction (DDI) studies.
Microsome technology significantly enhances our understanding of drug metabolism, playing a crucial role in the development of pharmacokinetics. Utilizing pooled microsomes, researchers can achieve greater consistency and reliability in metabolic stability assays. Despite these benefits, simply increasing the number of donors to standardize enzyme activities does not fully address all the factors that contribute to […]
The safety of newly developed lead compounds is often prioritized over efficacy. Additionally, the efficacy of a drug in a living organism may be compromised due to either too fast or too slow metabolism. Consequently, comprehensive Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADME-Tox) research becomes crucial for the development of new chemical entities. Drug metabolism […]